We independently review and compare the UK's leading methylation panels — analysing genes tested, lab standards, turnaround time, and value for money. No paid placements. No guesswork.
Tests we've analysed
Are you based in the UK?
Methylation clocks like Horvath's can estimate your biological age independently of your chronological age — and reveal how your lifestyle is affecting your rate of ageing at the cellular level.
Methyl groups act as molecular switches — turning genes on or off without altering the underlying DNA sequence. Understanding your pattern reveals which regulatory pathways are active in your body.
Abnormal methylation patterns are associated with cardiovascular disease, neurological conditions, and several cancers. Early identification creates opportunities for targeted lifestyle and nutritional intervention.
Our analysts assess each test on depth of analysis, lab accreditation, reporting clarity, support quality, and value per gene tested.
The most thorough methylation panel available to UK customers. Stride's in-house lab analyses 110 genes across 46 distinct reports, with a 10-day turnaround and a detailed online results portal. Best for those who want actionable depth without waiting weeks.
A clinically focused panel covering 78 genes, designed for use alongside practitioner support. Results are delivered by email with detailed interpretation guidance. Suited to those working with a functional medicine practitioner.
A premium-priced, protocol-oriented test focused on 13 key methylation genes. Designed around Gary Brecka's personalised supplementation approach. Best for those already familiar with Brecka's framework who want the companion test.
We examine the research behind methylation testing — where the evidence is solid, and where scepticism is warranted.
Every test on this site is assessed against the same framework: number of genes analysed, lab accreditation (ISO 15189 or equivalent), report clarity and actionability, customer support quality, turnaround time, and value per gene tested.
We receive affiliate commissions from providers we feature. These commissions never influence our ratings or recommendations — our scoring methodology is applied consistently and disclosed in full.
About us & our methodology →
"Most methylation test buyers have no way to compare what they're actually getting. We built this to change that."
Francesco Gatti, Founder & Lead Analyst
A DNA methylation test analyses specific genetic variants — typically SNPs (single nucleotide polymorphisms) — that affect how efficiently your body carries out methylation. This includes key genes like MTHFR, MTR, MTRR, CBS, and COMT. The results help identify whether your methylation cycle is over- or under-active, and can guide targeted nutritional or lifestyle interventions.
Methylation testing analyses your permanent genetic variants — the hardwired predispositions you were born with. Epigenetic testing (such as biological age clocks) measures how your current lifestyle and environment are influencing gene expression right now. They answer different questions and are complementary, not interchangeable. Read our full comparison →
For most UK customers, the Stride DNA Optimal Health panel offers the best combination of depth (110 genes, 46 reports), turnaround (10 days from an in-house UK lab), and price (£258). Those already working with a functional medicine practitioner may prefer Body Fabulous for its clinician-oriented reporting.
UK methylation tests range from around £120 for focused single-pathway panels to £499 for premium multi-gene analyses. Tests covering 70+ genes typically cost between £250 and £350. The cost per gene tested varies significantly between providers — our comparison table shows this metric for every test we've reviewed.
We receive affiliate commissions from providers we list — this is how we fund independent editorial work. These commissions are disclosed on every page where they apply. They do not influence our ratings, rankings, or editorial assessments, which are based on our published scoring methodology. Read our full disclosure →
