Methylation Research Papers.

Association of Polygenic Risk for Schizophrenia and DNA Methylation in the Brain

Published 24/09/2024

Schizophrenia is a complex psychiatric disorder with both genetic and environmental influences. Recent studies have pointed to the role of epigenetics, particularly DNA methylation, in the regulation of gene expression associated with the disorder.

Epigenetic Regulation in Cardiovascular Disease: Mechanisms and Advances in Clinical Trials

Published 19/08/2024

Cardiovascular disease (CVD) remains a leading cause of death worldwide, but understanding the mechanisms driving its progression is still evolving. This peer-reviewed study, published in Signal Transduction and Targeted Therapy, explores the role of epigenetic regulation in cardiovascular disease.

Genetic Variations, Methylation, and Gene Expression

Published 19/08/2024

While genetic variations (SNPs) are known to affect how our genes function, the mechanisms behind this influence are still being unraveled. One key area of interest is whether SNPs affect gene expression through DNA methylation—a process that acts like a dimmer switch for genes. A peer-reviewed study published in BMC Genomics addresses this question by exploring how genetic variations influence both methylation and gene expression.

Genetic Variants and Disease Biomarkers through Methylation

Published 19/08/2024

Methylation, a process that adds chemical markers to DNA, plays a key role in regulating gene expression. However, until recently, researchers were unclear about how much genetic variations, known as single nucleotide polymorphisms (SNPs), contributed to changes in DNA methylation and how this affects human health. A peer-reviewed study published in PLOS Genetics set out to explore this relationship, focusing on whether genetic variants influence DNA methylation and, in turn, disease-related protein biomarkers.

Genetic Polymorphisms in the Dopaminergic System and Response to Antipsychotic Treatment in Schizophrenia

Published 19/08/2024

Schizophrenia is a complex mental disorder with both genetic and environmental factors contributing to its development. Antipsychotic medications are the primary treatment, but individual responses to these drugs vary significantly.